pentobarbital will lessen the level or outcome of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of siponimod that has a drug that causes moderate CYP2C9 plus a reasonable or potent CYP3A4 inducer will not be encouraged.pentobarbital will lessen the level or influence of midostaur